Tulane was led by center Robinson Louisme who scored 12 points and five rebounds, and the Green Wave never trailed in the ballgame.
Louisme was joined in double figures by senior David Gomez who tallied 11 points, while Kevin Sims and Donnie Stith each scored 10 points. Stith and Matt Wheaton, both seniors, tied for the lead in rebounds with seven apiece. Sims posted a team-leading eight assists.
The Green Wave outshot Loyola early, hitting 57% of their first half shots to the Wolfpack's 36%. Loyola hit 6-of-11 from the three-point arc, while Tulane made 6-of-8 to take a 42-33 lead into the locker room.
Tulane, sparked by a pair of baskets by sophomore forward Asim McQueen, led by 13 points at 17-4 with less than five minutes elapsed in the first half.
Sophomore Eric Vianney, who debuted as a Green Wave player, hit a pair of three-pointers during the run.
Luke Zumo and Sean Bennett hit three-pointers to rally the Wolfpack and cut the Wave's lead to six points at 19-13, but Kevin Sims hit a three-pointer of his own to push the lead back to 9 points at 22-13.
The Wave went on a 9-0 run that extended their lead to 15 at 28-13 with less than 10 minutes remaining in the first half, led by Louisme's three baskets.
A trey by freshman Kris Richard with 1:34 remaining pushed the score to 42-27, but the Wolfpack scored the next four points of the half on a pair of free throws by Darrinto Moncrieffe and a three-pointer by Zumo.
Zumo, who scored 14 points in the opening stanza, scored the final poins of the half with 0:20 remaining to cut the Tulane lead to nine points at 42-33, and that's the way the half ended.
Tulane hit only 33.3% from the floor in the second half, going 0-10 from beyond the three-point line. But Loyola hit only 26% from the field in the second half and Zummo, who led all scorers with 17, was held to only 3 points in the second half.
The Green Wave outscored Loyola inside 34-14, 16-4 in the second half.
The Green Wave will open their regular season against Auburn in Fogleman Arena on Friday, November 9.