Tulae's record moves to 3-0 for the first time since the 2003-04 season. Nicholls State falls to 1-2.
The Colonels led by as many as 12 points twice in the first half, at 16-4 and 18-6, near the mid-point of the first half, but Tulane rallied, playing intense defense and pulled away in the second half.
Nicholls has now lost all 16 games in a series dating back to the 81-82 season.
Sims also distributed 8 assists.
Tulane went on a 20-1 run to take a 26-19 lead with 4:27 remaining in the half. Louisme led the Wave with 8 points during the run.
The Green Wave led the Colonels by seven points at the half at 35-28. Nicholls hit seven of it's first twelve shots, but from that point the Colonels cooled off and hit on only four of their last fifteen first-half shots.
It got worse in the second half as Tulane intensified their half court defensive pressure. The Colonels managed to score only 23 points in the second half, shooting 16.1 percent from the floor, on a 5-of-31 performance.
For the game, Nicholls shot 27.6 percent, 16-of-58, from the floor and 22.2 percent from beyond the three-point line.
The visitors opened the second half with a 9-to-4 run that cut the Tulane lead to 2 at 39-37 with 16:21 remaining. But from that point the Green Wave outscored the Colonels 25-6 to ice the ball game.
Eric Vianney hit two trey's and Louisme and Gomez each added four points to fuel that run.
Tulane will take Thanksgiving off before returning to action on Saturday, November 24 against cross-town rival University of New Orleans at Fogelman Arena. Tip-off is slated for 2 p.m.