Rob Kass's three touchdown passes led the Pirates, now 7-5 overall and 6-2 in Conference USA. For the night, Kass completed 12-of-18 passes for 177 yards.
Tulane, 4-8 overall and 3-5 in C-USA, was led by senior Matt Forte with 120 yards and one touchdown on 25 carries. Forte was 1-of-2 passing for 4 yards, and had 3 catches for 25 yards.
Jeremy Williams led all Wave receivers with 6 catches for 72 yards.
For the Pirates, Chris Johnson did the most damage, gaining 155 yards and three touchdowns on 27 carries.
East Carolina went three-and-out after taking the opening kickoff and after the punt, Tulane drove 49 yards in 11 plays to set up a 40-yard field goal by Ross Thevenot that gave the Wave the lead at 3-0.
But the Tulane lead was short-lived as the Pirates took the kickoff 71 yards on 7 plays capped by a six-yard scoring pass from Kass to Dominique Lindsay to give the Pirates a 7-3 lead.
After the score Tulane went three-and-out, but ECU's Dwayne Harris fumbled the Darren de Rochemont punt and the Wave's Michael Batiste recovered on the Pirate 23. After three plays the Greenies had gained but 5 yards and Ross Thevenot came on to boot a 35-yard field goal to cut the Pirate lead to 7-6.
The second quarter was all East Carolina as the Pirates extended their lead to 21-6 on a five-yard touchdown run by Johnson and a 25-yard scoring pass from Kass to Jamar Bryant.
ECU struck again in the third quarter when Johnson scored his second touchdown on a seven-yard run that capped a 10-play, 56-yard drive and made the score 28-6.
Tulane's Thevenot missed a 37-yard field goal attempt on Tulane's next possession, and ECU followed with a drive to the Green Wave 39 where Matt Dodge punted into the Tulane end zone.
The Wave then mounted a 9-play, 80-yard drive that Matt Forte completed with a three-yard scoring run to make the score 28-12. Tulane attempt to convert a two-point PAT failed when Anthony Scelfo's pass went incomplete.
The Green Wave then attempted an on-sides kick tht ECU recovered at the Tulane 40. On the second play after the kick Chris Johnson raced into the end zone for another score with a Rob Kass pass from the Tulane 33 and with the PAT the score moved to 35-12.
Matt Forte's quest to pass Mewelde Moore as the Green Wave's career rushing leader failed, as Forte finished his career with 4,265 yards, 99 yards behind Moore's 4,364.
Forte, who entered the game as the nation's leading rusher, finished the season with 2,127 yards but fell to second in the race for the season rushing title as Central Florida's Kevin Smith ended his season with 2,164 yards.
The East Carolina game wrapped Bob Toledo's first season as Tulane head coach. Toledo and his staff now turn their attention to recruiting.